Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus
Identifieur interne : 002B32 ( Main/Exploration ); précédent : 002B31; suivant : 002B33Differential effects of endocannabinoids on [3H]-GABA uptake in the rat globus pallidus
Auteurs : Katerina Venderov [Canada] ; Timothy M. Brown [Royaume-Uni] ; Jonathan M. Brotchie [Canada]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2005.
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Abstract
In the globus pallidus, cannabinoid CB1 receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [3H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [3H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB1 receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [3H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.
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Brown</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>School of Biological Sciences, University of Manchester</s1><s2>Manchester</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, MC 11-419</s1><s2>Toronto, Ontario, M5T 258</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario, M5T 258</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0317987</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0317987 INIST</idno><idno type="RBID">Pascal:05-0317987</idno><idno type="wicri:Area/PascalFrancis/Corpus">000901</idno><idno type="wicri:Area/PascalFrancis/Curation">000422</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000803</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000803</idno><idno type="wicri:doubleKey">0014-4886:2005:Venderov K:differential:effects:of</idno><idno type="wicri:Area/Main/Merge">002E71</idno><idno type="wicri:Area/Main/Curation">002B32</idno><idno type="wicri:Area/Main/Exploration">002B32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Differential effects of endocannabinoids on [<sup>3</sup>H]-GABA uptake in the rat globus pallidus</title><author><name sortKey="Venderov, Katerina" sort="Venderov, Katerina" uniqKey="Venderov K" first="Katerina" last="Venderov">Katerina Venderov</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, MC 11-419</s1><s2>Toronto, Ontario, M5T 258</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario, M5T 258</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Timothy M" sort="Brown, Timothy M" uniqKey="Brown T" first="Timothy M." last="Brown">Timothy M. Brown</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>School of Biological Sciences, University of Manchester</s1><s2>Manchester</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Toronto Western Research Institute, Toronto Western Hospital, 399 Bathurst Street, MC 11-419</s1><s2>Toronto, Ontario, M5T 258</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario, M5T 258</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Basal ganglion</term><term>CB1 cannabinoid receptor</term><term>Cannabinoid</term><term>GABA</term><term>Gabaergic neuron</term><term>Glycerol</term><term>Parkinson disease</term><term>Rat</term><term>Uptake</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Cannabinoïde</term><term>GABA</term><term>Captation</term><term>Animal</term><term>Rat</term><term>Récepteur cannabinoïde CB1</term><term>Neurone gabaergique</term><term>Glycérol</term><term>Noyau gris central</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the globus pallidus, cannabinoid CB<sub>1</sub> receptors are localized pre-synaptically on GABAergic neurons. We assessed the influence of the endocannabinoids, anandamide, 2-arachidonoyl-glycerol (2-AG) and noladin ether, on the uptake of [<sup>3</sup>H]-GABA in pallidal slices from rat. Both 2-AG and noladin ether increased [<sup>3</sup>H]-GABA uptake (by 40.8 ± 8.0% and 38.4 ± 12.5%). The effect of 2-AG was blocked by the cannabinoid CB<sub>1</sub> receptor antagonist AM 251. In contrast, neither anandamide nor the agonist WIN 55,212-2 had an effect on [<sup>3</sup>H]-GABA uptake. Different roles might be played by different endocannabinoids, both physiologically and in basal ganglia disorders, such as Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Manchester</li></region><settlement><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Venderov, Katerina" sort="Venderov, Katerina" uniqKey="Venderov K" first="Katerina" last="Venderov">Katerina Venderov</name></noRegion><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M." last="Brotchie">Jonathan M. Brotchie</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brown, Timothy M" sort="Brown, Timothy M" uniqKey="Brown T" first="Timothy M." last="Brown">Timothy M. 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